Human TEL-AML1 Fusion Gene Mutation
Product name
HWTS-TM016 Human TEL-AML1 Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Epidemiology
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. In recent years, acute leukemia (AL) has changed from MIC type (morphology, immunology, cytogenetics) to MICM type (addition of molecular biology testing). In 1994, it was discovered that TEL fusion in childhood was caused by nonrandom chromosomal translocation t(12;21)(p13;q22) in B-lineage acute lymphoblastic leukemia (ALL). Since the discovery of the AML1 fusion gene, the TEL-AML1 fusion gene is the best way to judge the prognosis of children with acute lymphoblastic leukemia.
Channel
| FAM | TEL-AML1 fusion gene |
| ROX |
Internal Control |
Technical Parameters
| Storage |
≤-18℃ |
| Shelf-life | 9 months |
| Specimen Type | bone marrow sample |
| Ct | ≤40 |
| CV | <5.0% |
| LoD | 1000Copies/mL |
| Specificity | There is no cross-reactivity between the kits and other fusion genes like BCR-ABL, E2A-PBX1, MLL-AF4, AML1-ETO, PML-RARa fusion genes. |
| Applicable Instruments | Applied Biosystems 7500 Real-Time PCR Systems
Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
Work Flow
RNAprep Pure Blood Total RNA Extraction Kit (DP433).
