Human BCR-ABL Fusion Gene Mutation

Short Description:

This kit is suitable for qualitative detection of p190, p210 and p230 isoforms of the BCR-ABL fusion gene in human bone marrow samples.

Product Detail

Product Tags

Product name

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR )


Chronic myelogenousleukemia (CML) is a malignant clonal disease of hematopoietic stem cells. More than 95% of CML patients carry the Philadelphia chromosome (Ph) in their blood cells. Predominant pathogenesis of CML is as follows: The BCR-ABL fusion gene is formed by a translocation between the abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) on the long arm of chromosome 9 (9q34) and the breakpoint cluster region (BCR) gene on the long arm of chromosome 22 (22q11) ; the fusion protein encoded by this gene has tyrosine kinase (TK) activity, and activates its downstream signaling pathways (such as RAS, PI3K, and JAK/STAT) to promote cell division and inhibit cell apoptosis, making cells proliferate malignantly, and thereby causing the occurrence of CML . BCR-ABL is one of the important diagnostic indicators of CML. The dynamic change of its transcript level is a reliable indicator for prognostic judgment of leukemia and can be used to predict the recurrence of leukemia after treatment.


FAM BCR-ABL fusion gene
VIC/HEX Internal Control

Technical Parameters

Storage Liquid: ≤-18℃ In dark
Shelf-life Liquid: 9 months
Specimen Type Bone marrow samples
LoD 1000 Copies/ mL



There is no cross-reactivity with other fusion genes TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, and PML-RARa
Applicable Instruments Applied Biosystems 7500 Real-Time PCR Systems

Applied Biosystems 7500 Fast Real-Time PCR Systems

QuantStudio® 5 Real-Time PCR Systems

SLAN-96P Real-Time PCR Systems

LightCycler®480 Real-Time PCR system

LineGene 9600 Plus Real-Time PCR Detection System

MA-6000 Real-Time Quantitative Thermal Cycler

BioRad CFX96 Real-Time PCR System

BioRad CFX Opus 96 Real-Time PCR System

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